/* Cysteine Reactivity Atlas: typography and colors follow nomuraresearchgroup.com (theme "nomura", captured 2026-10-09).
   Gellix is the lab site's licensed webfont, loaded from the lab's own theme; system fonts are the fallback. */
@font-face{font-family:gellix;font-weight:400;font-display:swap;src:url("https://nomuraresearchgroup.com/wp-content/themes/nomura/assets/fonts/gellix-regular-webfont.woff2") format("woff2")}
@font-face{font-family:gellix;font-weight:500;font-display:swap;src:url("https://nomuraresearchgroup.com/wp-content/themes/nomura/assets/fonts/gellix-medium-webfont.woff2") format("woff2")}
@font-face{font-family:gellix;font-weight:600;font-display:swap;src:url("https://nomuraresearchgroup.com/wp-content/themes/nomura/assets/fonts/gellix-semibold-webfont.woff2") format("woff2")}

:root{
  --ink:#171738; --heading:#19153c; --nav:#253652; --text:#45455e; --muted:#6b6b85;
  --blue:#3f76f0; --blue-soft:#e8effd; --indigo:#1b1564; --bg:#f6f7f8; --card:#ffffff; --line:#e3e3e7;
  --green:#14a37f; --amber:#b86e00; --amber-soft:#fff4e0; --red:#c23b3b;
  --font:gellix, "Segoe UI", system-ui, -apple-system, Roboto, Helvetica, Arial, sans-serif;
  --mono:ui-monospace, "SFMono-Regular", Menlo, Consolas, monospace;
}
*{box-sizing:border-box}
html{scroll-behavior:smooth}
body{margin:0;font:400 17px/1.55 var(--font);color:var(--text);background:var(--bg);-webkit-font-smoothing:antialiased}
a{color:var(--blue);text-decoration:none}a:hover{text-decoration:underline}
.wrap{max-width:1240px;margin:0 auto;padding:0 32px}
@media (max-width:640px){.wrap{padding:0 16px}body{font-size:16px}}

/* header */
.site-header{background:rgba(255,255,255,.95);border-bottom:1px solid var(--line);position:sticky;top:0;z-index:20;backdrop-filter:saturate(1.2) blur(6px)}
.header-row{display:flex;align-items:center;justify-content:space-between;min-height:88px;gap:24px;flex-wrap:wrap}
.brand img{display:block;height:46px;width:auto}
.main-nav{display:flex;gap:30px;flex-wrap:wrap}
.main-nav a{color:var(--nav);font-weight:500;font-size:17px}
.main-nav a.on{color:var(--blue)}
.main-nav a.ext::after{content:" ↗";font-size:13px}
@media (max-width:640px){.header-row{min-height:70px;padding-top:10px;padding-bottom:10px}.brand img{height:36px}.main-nav{gap:18px}.main-nav a{font-size:15px}}

/* type */
h1,h2,h3{color:var(--heading);font-weight:400;margin:0}
.hero{padding:64px 0 28px}
.hero h1{font-size:clamp(44px,7vw,92px);line-height:1;letter-spacing:-.01em}
.hero h1 span{color:var(--blue)}
.lead{font-size:clamp(17px,1.6vw,21px);line-height:1.55;max-width:780px;margin:22px 0 0;color:var(--text)}
.page-title{padding:44px 0 6px}
.page-title h1{font-size:clamp(34px,4.5vw,56px);line-height:1.05}
.page-title h1 small{font-size:.42em;color:var(--muted);margin-left:10px;font-weight:400}
.kicker{text-transform:uppercase;letter-spacing:.12em;font-size:13px;font-weight:600;color:var(--blue);margin:0 0 10px}
h2.section{font-size:clamp(24px,2.6vw,32px);margin:52px 0 16px;display:flex;align-items:baseline;gap:14px;flex-wrap:wrap}
h2.section::before{content:"";display:inline-block;width:44px;height:2px;background:var(--blue);transform:translateY(-8px)}
.sub{color:var(--muted);font-size:15px;margin:6px 0 0}

/* search */
.search{position:relative;max-width:760px;margin-top:34px}
.search input{width:100%;font:400 19px var(--font);color:var(--ink);padding:18px 22px 18px 54px;border:1px solid var(--line);border-radius:999px;background:#fff;box-shadow:0 10px 30px rgba(23,23,56,.06)}
.search input:focus{outline:none;border-color:var(--blue);box-shadow:0 0 0 4px var(--blue-soft)}
.search::before{content:"";position:absolute;left:22px;top:50%;width:16px;height:16px;border:2px solid var(--muted);border-radius:50%;transform:translateY(-62%)}
.search::after{content:"";position:absolute;left:36px;top:58%;width:8px;height:2px;background:var(--muted);transform:rotate(45deg)}
.suggest{position:absolute;left:0;right:0;top:calc(100% + 8px);background:#fff;border:1px solid var(--line);border-radius:18px;box-shadow:0 20px 40px rgba(23,23,56,.12);overflow:hidden;z-index:10}
.suggest a{display:grid;grid-template-columns:110px 110px 1fr auto;gap:12px;align-items:center;padding:11px 20px;color:var(--ink);border-top:1px solid var(--line);font-size:15px}
.suggest a:first-child{border-top:0}
.suggest a:hover,.suggest a.sel{background:var(--blue-soft);text-decoration:none}
.suggest .g{font-weight:600}.suggest .d{color:var(--muted);white-space:nowrap;overflow:hidden;text-overflow:ellipsis}
@media (max-width:640px){.suggest a{grid-template-columns:80px 1fr auto}.suggest .acc{display:none}}
.hint{margin-top:12px;font-size:14px;color:var(--muted)}.hint a{margin-right:12px}

/* cards and tiles */
.tiles{display:grid;grid-template-columns:repeat(auto-fit,minmax(180px,1fr));gap:14px;margin:30px 0 0}
.tile{background:var(--card);border:1px solid var(--line);border-radius:16px;padding:18px 20px}
.tile .n{font-size:32px;color:var(--heading);line-height:1.1;font-variant-numeric:tabular-nums}
.tile .n .b{color:var(--blue)}
.tile .l{font-size:14px;color:var(--muted);margin-top:4px}
.panel{background:var(--card);border:1px solid var(--line);border-radius:18px;padding:22px 24px}
.grid2{display:grid;grid-template-columns:1fr 1fr;gap:18px}
@media (max-width:860px){.grid2{grid-template-columns:1fr}}

/* chips and flags */
.chip{display:inline-block;font-size:12px;line-height:1;padding:5px 9px;border-radius:999px;background:var(--blue-soft);color:var(--nav);margin:0 4px 0 0;white-space:nowrap;vertical-align:middle}
.chip.warn{background:var(--amber-soft);color:var(--amber)}
.chip.ok{background:#e3f6f0;color:#0b7a5e}
.chip.mute{background:#eeeef2;color:var(--muted)}
.ip2{color:var(--green)}
.y20{color:var(--blue)}

/* controls */
.controls{display:flex;flex-wrap:wrap;gap:14px 26px;align-items:center;margin:20px 0 6px;font-size:14px;color:var(--muted)}
.seg{display:inline-flex;border:1px solid var(--line);border-radius:999px;background:#fff;overflow:hidden;margin-left:8px}
.seg button{font:500 13px var(--font);color:var(--nav);background:none;border:0;padding:7px 14px;cursor:pointer}
.seg button.on{background:var(--ink);color:#fff}
.controls label{cursor:pointer;display:inline-flex;align-items:center;gap:6px}
.btn{display:inline-block;font:600 13px var(--font);text-transform:uppercase;letter-spacing:.04em;color:#fff;background:var(--blue);border:0;border-radius:999px;padding:11px 20px;cursor:pointer}
.btn:hover{text-decoration:none;background:#2f63d8}
.btn.ghost{background:#fff;color:var(--nav);border:1px solid var(--line)}

/* tables */
.tablewrap{overflow-x:auto;background:var(--card);border:1px solid var(--line);border-radius:16px}
table{width:100%;border-collapse:collapse;font-size:15px}
th,td{padding:11px 14px;border-bottom:1px solid var(--line);text-align:left;vertical-align:middle}
th{font-size:12px;font-weight:600;text-transform:uppercase;letter-spacing:.06em;color:var(--muted);background:#fafafb;white-space:nowrap;position:sticky;top:0}
th.sort{cursor:pointer}th.sort:hover{color:var(--ink)}
tr:last-child td{border-bottom:0}
tbody tr:hover{background:#fbfbfd}
td.num,th.num{text-align:right;font-variant-numeric:tabular-nums}
td.mono,.mono{font-family:var(--mono);font-size:13px}
td.nw{white-space:nowrap}
.more{margin:12px 0 0}

/* charts */
.track{position:relative;height:46px;background:linear-gradient(var(--blue-soft),var(--blue-soft)) center/100% 10px no-repeat;margin:18px 0 6px}
.track i{position:absolute;top:6px;width:4px;height:34px;margin-left:-2px;border-radius:2px;background:#9db8f6}
.track i.hot{background:var(--blue)}.track i.sus{background:var(--amber)}
.track i:hover{transform:scaleX(1.8)}
.track-axis{display:flex;justify-content:space-between;font-size:12px;color:var(--muted)}
.bars{display:flex;align-items:flex-end;gap:6px;height:150px;margin-top:26px}
.bars .col{flex:1;min-width:14px;height:100%;position:relative;display:flex;flex-direction:column-reverse}
.bars .col i{display:block}.bars .col i.a{background:var(--blue)}.bars .col i.b{background:var(--green)}
.bars .col i:last-of-type{border-radius:4px 4px 0 0}
.bars .col b{position:absolute;left:0;right:0;text-align:center;font-size:11px;font-weight:600;color:var(--ink);transform:translateY(-110%)}
.bars .col span{position:absolute;bottom:-22px;left:0;right:0;text-align:center;font-size:11px;color:var(--muted)}
.legend{font-size:13px;color:var(--muted);margin-top:30px}.legend i{display:inline-block;width:10px;height:10px;border-radius:2px;margin:0 6px 0 14px;vertical-align:-1px}
.legend i:first-child{margin-left:0}.legend i.a{background:var(--blue)}.legend i.b{background:var(--green)}
.hbar{display:grid;grid-template-columns:90px 1fr 80px;gap:10px;align-items:center;font-size:14px;margin:8px 0}
.hbar div{height:14px;background:var(--blue-soft);border-radius:7px;overflow:hidden}.hbar div i{display:block;height:100%;background:var(--blue)}

/* prose */
.prose{max-width:820px}.prose p,.prose li{font-size:17px}.prose h3{font-size:22px;margin:30px 0 8px}
.prose code{font-family:var(--mono);font-size:14px;background:#eeeef2;padding:1px 5px;border-radius:4px}
.note{background:var(--amber-soft);border-radius:14px;padding:14px 18px;color:#6b4300;font-size:15px;margin:18px 0}
.loading{padding:80px 0;color:var(--muted)}

/* footer */
.site-footer{background:var(--indigo);color:#fff;margin-top:80px;padding:46px 0}
.footer-grid{display:grid;grid-template-columns:1.4fr 1fr;gap:30px}
.footer-title{font-size:24px;margin-bottom:8px}
.site-footer p{margin:6px 0;color:rgba(255,255,255,.85)}
.site-footer .fine{font-size:13px;color:rgba(255,255,255,.65);line-height:1.6}
.site-footer a{color:#fff;text-decoration:underline}
@media (max-width:760px){.footer-grid{grid-template-columns:1fr}}

/* phone: two tiles per row (kept last so it overrides .tiles above) */
@media (max-width:640px){.tiles{grid-template-columns:1fr 1fr;gap:10px}.tile{padding:14px}.tile .n{font-size:24px}.tile .l{font-size:13px}}

/* ---- added October 12, 2026: confidence tiers, annotations, sequence viewer, browse, batch ---- */
.chip.feat{background:#efe9fb;color:#5b3aa8}
.chip.fam{background:#e6f1ff;color:#1f4fb3}
.chip.dep{background:#fff1f1;color:#a33a3a}
.chip.pred{background:#fff7e6;color:#8a5a00;font-family:var(--mono);font-size:12px}
table.tiers{font-size:14px}table.tiers th,table.tiers td{padding:8px 10px}
.track i.lo{background:#cfd9f3;height:22px;top:12px}
.cards{display:grid;grid-template-columns:repeat(auto-fit,minmax(230px,1fr));gap:14px}
.card{display:block;background:var(--card);border:1px solid var(--line);border-radius:16px;padding:18px 20px;color:var(--text)}
.card:hover{text-decoration:none;border-color:var(--blue);box-shadow:0 10px 24px rgba(23,23,56,.08)}
.card .n{font-size:28px;color:var(--heading);line-height:1.1;font-variant-numeric:tabular-nums;min-height:31px}
.card .t{font-weight:600;color:var(--ink);margin-top:6px}
.card .x{font-size:14px;color:var(--muted);margin-top:4px;line-height:1.45}
.filters{display:flex;flex-wrap:wrap;gap:10px 18px;align-items:center;margin:18px 0 10px;font-size:14px;color:var(--muted)}
.filters label{display:inline-flex;align-items:center;gap:6px}
.filters select,.filters input{font:400 14px var(--font);color:var(--ink);padding:7px 10px;border:1px solid var(--line);border-radius:10px;background:#fff}
textarea{width:100%;max-width:760px;font:400 15px var(--mono);color:var(--ink);padding:14px 16px;border:1px solid var(--line);border-radius:14px;background:#fff;resize:vertical}
textarea:focus{outline:none;border-color:var(--blue);box-shadow:0 0 0 4px var(--blue-soft)}
td.d{color:var(--muted);font-size:14px;max-width:320px;overflow:hidden;text-overflow:ellipsis;white-space:nowrap}
.kv{display:grid;grid-template-columns:110px 1fr;gap:8px 14px;margin:8px 0 0;font-size:15px}
.kv dt{color:var(--muted);font-size:13px;text-transform:uppercase;letter-spacing:.06em;padding-top:3px}
.kv dd{margin:0}
/* sequence viewer */
.seq{font:400 13.5px/1.9 var(--mono);background:var(--card);border:1px solid var(--line);border-radius:14px;padding:14px 18px;overflow:auto;letter-spacing:.04em;color:var(--text);margin:0}
.seq.clip{max-height:330px}
.seq.win{font-size:16px;overflow:visible;display:inline-block}
.seq .pos{color:var(--muted);font-size:11px;margin-right:4px}
.seq .c{display:inline-block;border-radius:4px;padding:0 2px;margin:0 -1px;font-weight:600;line-height:1.35}
.seq a.c:hover{text-decoration:none;outline:2px solid var(--ink)}
.c-h{background:var(--blue);color:#fff}
.c-m{background:#9db8f6;color:#fff}
.c-l{background:#e3e8f6;color:#5a6a9a}
.c-hid{background:#fff;color:var(--blue);box-shadow:inset 0 0 0 1.5px var(--blue)}
.c-pred{background:#fff;color:#8a5a00;box-shadow:inset 0 0 0 1.5px #e0a52a}
.c-none{background:#f1f1f4;color:var(--muted);font-weight:400}
.seqlegend{display:flex;flex-wrap:wrap;align-items:center;gap:6px 4px;font-size:13px;color:var(--muted);margin:0 0 10px}
.seqlegend i{display:inline-block;width:14px;height:14px;border-radius:4px;margin:0 2px 0 12px;vertical-align:-2px}
.seqlegend i:first-child{margin-left:0}
@media (max-width:640px){.kv{grid-template-columns:1fr}.seq{font-size:12px}}
/* AlphaFold structure viewer */
.struct{padding:14px 16px}
.structhead{display:flex;flex-wrap:wrap;gap:10px 16px;align-items:center;justify-content:space-between;margin-bottom:10px}
.viewer{position:relative;height:480px;border-radius:12px;overflow:hidden;background:var(--bg)}
.viewer canvas{border-radius:12px}
.struct-legend{display:flex;flex-wrap:wrap;align-items:center;gap:4px;font-size:13px;color:var(--muted);margin-top:10px}
.struct-legend i{display:inline-block;width:18px;height:8px;border-radius:2px;margin:0 2px 0 10px;vertical-align:1px}
.struct-legend i.dot{width:11px;height:11px;border-radius:50%}
.struct-legend i:first-child{margin-left:0}
@media (max-width:640px){.viewer{height:340px}}
.struct-legend .sub{flex-basis:100%;margin:6px 0 0 !important}
/* consolidated peptide evidence (expandable per cysteine) */
.pep-toggle{font:500 13px var(--font);color:var(--blue);background:var(--blue-soft);border:0;border-radius:999px;padding:5px 10px;cursor:pointer;white-space:nowrap}
.pep-toggle:hover{background:#d8e4fb}
tr.pep-row>td{background:#fafbfe;padding:8px 14px 14px}
table.peps{font-size:14px;width:100%}
table.peps th{position:static;background:none;border-bottom:1px solid var(--line)}
table.peps td{padding:8px 10px;vertical-align:top}
table.peps td.forms{font-size:13px;line-height:1.7}
table.peps tr.total td{border-top:2px solid var(--line);font-weight:600;color:var(--ink)}
table.peps tr.total td.sub{font-weight:400}
.see3d{font:600 11px var(--font);color:var(--nav);background:#fff;border:1px solid var(--line);border-radius:999px;padding:3px 8px;cursor:pointer;vertical-align:1px;margin-left:4px}
.see3d:hover{border-color:#d9730d;color:#d9730d}
/* October 13, 2026: predicted-but-undetected cysteines as rows with a "3D" button */
table.predtab{font-size:14px;margin-top:4px}
table.predtab th{position:static;background:none;padding:6px 8px}
table.predtab td{padding:6px 8px}
.panel table.predtab tbody tr:hover{background:#fffaf0}
/* phone fixes (October 13): tier tables scroll inside their panel; the protein page's site table and predictions stack */
.tierwrap{overflow-x:auto}
.grid2.grid-wide{grid-template-columns:1.7fr 1fr}
.grid2>*{min-width:0}
@media (max-width:860px){.grid2.grid-wide{grid-template-columns:1fr}}
@media (max-width:640px){table.tiers th{white-space:normal}table.tiers td,table.tiers th{padding:6px 6px}}